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The Vital Function of Myelin
Development and Maintenance:
targeting periventricular leukomalacies and leukodystrophies
Scientific Committee : Patrick Aubourg, Monique Dubois-Dalcq, Annick Baron Van Evercooren, Odile Boespflug-Tanguy, Thierry Lacaze.
Hôtel
Concorde
Lafayette
3, place du général Koening
75017 Paris
Tel. : (33) 01.40.68.50.68
PARIS - October 5, 6, 7, 2006 |
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Thursday, October 5, 2006
2:00-7:05 pm |
Myelin Development and Repair
Chairs : Robin Franklin (Center for Brain Repair, University of Cambridge, Cambridge - UK),
Anne Baron-Van Evercooren (Inserm U546, CHU Pitié-Salpétrière Paris – France)
| 2:00 pm |
Introduction - Robin Franklin |
| 2:10 pm |
A role for VGEF-C and VEGFR-3 in neural cell development - Jean Léon ThomaS (Inserm U.711, Université Pierre et Marie Curie CHU Pitié Salpétrière, Paris - France) |
| 2:40 pm |
Intrinsic regulators of oligodendrocyte progenitor proliferation and differentiation - Vittorio GALLO (Center for Neuroscience Research, Washington - USA) |
| 3:10 pm |
Adult neural stem cells for myelin repair- Pascale Durbec (IBDML - UMR 6216 Parc Scientifique de Luminy, Marseille - France) |
| 3:40 pm |
Coffee Break |
| 4:00 pm |
Poster Session (session 1 et 2) |
| 5:30 pm |
Embryonic stem cells for CNS myelin diseases - Hans Keirstead (Dpt Anatomy & Neurobiology, University of California, Irvine - USA) |
| 6:00 pm |
Redundant and non-redundant mediators of remyelination - finding the therapeutic targets - Robin Franklin (Center for Brain Repair, University of Cambridge, Cambridge - UK) |
| 6:30 pm |
Exploring oligodendrogenesis from Human neural stem cells for myelin repair and myelin repair / Concluding remarks - A.Baron Van Evercooren (Inserm U.546, CHU Pitié-Salpétrière, Paris – France) |
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Friday, October 6, 2006
9:00-12:15 am |
Mechanism of glial cell and axonal pathology in CNS myelin disorders
Chairs: Francesca Aloisi (Dept Cell Biology & Neuroscience Instituto Sup. di Sanita, Roma - Italy)
Monique Dubois-Dalcq (Porter Neuroscience Research Center, NIH, Bethesda – USA)
| 9:00 am |
Myelin/axon interactions: lessons from animal models - Klaus-Armin Nave (Dpt Neurogenetics, Max Planck Institute, Goettingen - Germany) |
| 9:30 am |
The development of oligodendrocytes in early-onset leukodystrophies - Ian Duncan (Dpt Medical Sciences, School Veterinary Medecine, University Wisconsin, Madison - USA) |
| 10:00 am |
Glycosaminoglycan as signals for remyelination failure - Larry Sherman (Dpt. Neurosciences, Oregon Health & Science University, Beaverton, Oregon - USA) |
| 10:30 am |
Coffee Break |
| 11:00 am |
Mechanisms of excitotoxic damage to white matter- Carlos Matute (Dept Neurosciencias, Universitad del Pais Vasco, Viszcaya - Spain) |
| 11:30 am |
Neurotransmitter signalling to oligodendrocytes and its role in white matter disease - David Attwell (Dpt Physiology, University College London, London - UK) |
| 12:00 am |
Summary/Concluding remarks - Monique Dubois-Dalcq (Porter Neuroscience Research Center, NIH, Bethesda – USA) |
| 12:15 pm |
Lunch/Buffet |
| 1:30 pm |
Poster session (session 3 and 4) |
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Friday, October 6 2006
3:30-6:45 pm |
White matter disease of the premature
Chairs: Thierry Lacaze (Dpt Obstetrics & Gynecology, University Alberta, Edmonton-Canada)
Patrick Aubourg (Inserm U.745, Paris – France)
| 3:30 pm |
White matter disease of the premature - Thierry Lacaze |
| 4:10 pm |
MRI of the white matter disease of prematurity - Mary Rutherford (The Robert Steiner MR Unit, Imperial College Medicine, london - UK) |
| 4:40 pm |
Coffee Break |
| 5:00 pm |
White matter of the premature: animal models - Pierre Gressens (Inserm U.676, Service Neurologie Pédiatrique, Hôpital R. Debré, Paris - France) |
| 5:30 pm |
The adaptive immune response in neonatal cerebral white matter damage - Olaf Dammann (Perinatal Infection Disease Epidemiology Unit, Hannover medical school, Hannover - Germany) |
| 6:00 pm |
Mechanisms of oligodendrocyte death in the white matter disease of the premature - Frances Jensen (Division Neurosciences, Children's Hospital, Boston - USA) |
| 6:30 pm |
Concluding remarks - Patrick Aubourg (Inserm U.745, Paris – France) |
| 8:00 pm |
Dinner |
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Saturday, October 7 2006
8:30-11:00 |
Genetics and Therapeutics of Leukodystrophies
Astrocytes, a new target for leukodystrophies
Chairs: Jutta Gartner (Dept Pediatric Neurology, University Gôttingen,Gôttingen – Germany)
| 8:30 am |
Introduction - Jutta Gartner |
| 8:35 am |
Alexander disease: a large clinical spectrum - Diana Rodriguez (Unité Neuropathologie & Service Neuropédiatrie, Hôpital Trousseau, Paris - France) |
| 8:50 am |
Alexander disease: a protein aggregation pathology - Danielle Pham Dinh (Inserm U 546, Université Paris 6, Paris - France) |
| 9:15 am |
EIF2B deficiency: Selective Vulnerability of CNS Glial Cells - Raphael Schifmann (NIH, Bethesda – USA) |
| 9:40 am |
EIF2B deficiency: a stress-induced pathology ? - Orna Elroy Stein (Dpt Cell Research & Immunology, Tel Aviv University, Tel Aviv - Israel) |
| 10:00 am |
The cystic leukoencephalopathies - Enrico Bertini (Unit of Molecular Medicine, Bambino Gesu' Children's Research Hospital, Rome – Italy) |
| 10:15 am |
MLC1 leukoencephalopathy - Elena Ambrosini (Dept Cell Biology & Neuroscience Instituto Superiore di Sanita, Roma - Italy) |
| 10:30 am |
Coffee Break |
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Saturday, October 7, 2006
11:00-12:30 am |
Genetics and Therapeutics of Leukodystrophies
Therapeutic Approaches of Leukodystrophies
Chair: Odile Boespflug Tanguy (Inserm U.384, Faculté de Médecine, Clermont-Ferrand – France)
| 11:00 am |
Introduction Odile Boespflug Tanguy |
| 11:05 am |
Screening Compounds to Ameliorate EIF2B Deficiency - Graham Pavitt (Faculty of Sciences, University of Manchester, Manchester - UK) |
| 11:35 am |
Gene and Cell therapy in leukodystrophies - Patrick Aubourg (Inserm U.561, Service Endocrinologie Pédiatrique, Hôpital Saint-Vincent de Paul, Paris - France) |
| 11:50 am |
Combined therapies for the treatment of Krabbe disease - David Wenger (Jefferson Medical college, Philadelphia - USA) |
| 12:05 am |
Inhibiting PLP gene mutations - Franca Cambi (Dept. Neurology, Chandler Medical Center, University Kentucky, Lexington - USA) |
| 12:20-am |
Concluding remarks - Jutta Gattner (Dept Pediatrics & Pediatric Neurology, University Gôttingen, Gôttingen – Germany) |
| 12:30 pm |
Lunch/Buffet |
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